Description

Oral thin film: A novel approach in fast dissolving drug delivery

1.1 Introduction

Considering oral administration accounts for over 52% of the market for drug delivery overall, there has been a lot of interest in the development of modified-release oral dosage forms. The pharmaceutical industry’s sources of drug leads have seen a tremendous shift in recent years (Milián-Guimerá et al., 2023). However, there are some issues that are frequently connected to the oral administration of medications that reduce the danger of partial active component loss through tablet or capsule crushing or inaccurate liquid administration, which causes dose errors and overdosing or ineffective drug therapy. The screening regions of absorption, distribution, metabolism, and excretion follow the idea of large chemical space and narrow target space (Vrbanac et al., 2017).

Fast-dissolving medication delivery systems are getting a lot of attention as a solution to these problems. In recent years, oral film strips have become popular as a brand-new method of breath freshening. These wafers, which resemble gel, disintegrate swiftly in the mouth to release flavor. Many pharmaceutical corporations have been diverted by recent technical breakthroughs to investigate new possibilities in this technology to give quick, accurate dosing that is anticipated to grow compliance, especially among young people. Transmucosal methods of drug administration have developed significantly in recent years because they have the potential to solve issues related to oral medication administration. The dose of medicine is swallowed after melting without the use of water or measurement. Because the mouth mucosa is highly vascularized and hence extremely permeable, absorbing drugs through it into the systemic circulation is a desirable strategy. As a result, fast-dissolving films have gained popularity as an oral dosage form for many medications since they offer quick disintegration due to their huge surface area (Bala et al., 2018).