Description

Since from the last 40 years, the concept of mucoadhesion has provided the great application
in prolonging the residence time as well as controlled release of various bioadhesive dosage
forms through different mucosal routes. Formulations based on the mucoadhesive drug
delivery system have shown the enhanced bioavailability of many drugs. use of various
mucoadhesive polymers have achieved the signicant interest in formulating the sustained
release, extended release as well as prolonged release dosage forms (Mansuri et al., 2016).
mucoadhesive drug delivery provides greater absorption and enhanced bioavailability of
dosage forms due to the large surface area and higher blood in the mucosal cavities. Delivery
across the mucus membrane provides various advantages over other drug delivery routes i.e.,
overcome the hepatic pass metabolism as well as the degradation of drugs by various
gastrointestinal enzymes as well as intestinal oral. For the desired mucoadhesive strength of
the mucoadhesive dosage forms, there are various mucoadhesive polymers that can be used
(Yang et al., 2017). Polymers are either natural or synthetic macromolecules which are
capable of adhering to the mucosal surfaces. From last three decades, the use of various
Mucoadhesive polymers has achieved a great interest in the of pharmaceutical technology.
Nowadays, the use of mucoadhesive polymers has been accepted as an important strategy to
prolong the residence time and to improve the localized of drug delivery systems on various
mucus membranes (Sharma et al., 2023).